DREAM/Calsenilin/KChIP3:神经系统的多功能蛋白

作者:张瑛;王韵 刊名:生理科学进展 上传者:仝德

【摘要】新近发现的转录因子DREAM(downstreamregulatoryelementantagonistmodulator)可结合到基因(包括PPD、Hrk、cfos等)的DRE(downstreamregulatoryelement)位点,抑制基因转录。它是第一个已知的可以直接与DNA结合发挥转录抑制作用的Ca2+结合蛋白,为Ca2+调节基因表达除蛋白激酶/磷酸酶这条主要通路外提供了另一条通路。由于DREAM与另两个研究小组发现的蛋白calsenilin和KChIP3实为同一种物质,所以DREAM具有PS(presenilin)作用蛋白、Kv4通道调节蛋白和转录因子的多重功能特性。本文将就DREAM的分布、功能及其调控、DREAM与疼痛的关系作简要综述。

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DREAM/Calsenilin/KChiP3:神经系统的多功能蛋白术 张 瑛 王 韵△(北京大学神经科学研究所,神经科学教育部重点实验室,北京100083) 摘要 新近发现的转录因子DREAM(downstream regulatory element antagonist modulator)可结合到基因(包括PPD、Hrk、c—fos等)的DRE(downstream regulatory element)位点,抑制基因转录。它是第 一个已知的可以直接与DNA结合发挥转录抑制作用的Ca2+结合蛋白,为Ca2+调节基因表达除蛋白激酶/磷酸酶这条主要通路外提供了另一条通路。由于DREAM与另两个研究小组发现的蛋白calsenilin和KChIP3实为同一种物质,所以DREAM具有PS(presenilin)作用蛋白、Kv4通道调节蛋白和转录园子的多重功能特性。本文将就DREAM的分布、功能及其调控、DREAM与疼痛的关系作简要综述。 关键词 DREAM/Calsenilin/KChIP3;钙离子;基因表达调控;强啡肽;疼痛中图分类号Q426 DREAM/Calsenilin/KChIP3:A New Multifunctional Protein in Nervous System ZHANG Ying, WANG Yun(Neuroscience Research Institute,Peking University.Key Laboratory of Neuroscieuce,Ministry of Education,Beijing 100083) Abstract A newly found transcription factor—DREAM can bind specifically with downstream regulatory element of genes,such as PPD,Hrk and c-Fos,and repress gene expression.It represents the first known Ca2+binding protein to function as a DNA—binding transcription regulator.This provides a new mecha-nism of Ca2+dependent regulation of gene expression in addition to protein kinase/phosphatase signaling pathway.In fact,DREAM,calsenilin and KChIP3,which are identified by different laboratories,are the same protein.So DREAM is a muhifunctional protein,including PS interacting protein,Kv4 reguratory protein and transcription factor.The distribution,function and regulation of DREAM,as well as relation— ship between DREAM and pain,are reviewed in the present article. Key words DREAM/Calsenilin/KChlP3;Calciu

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