细胞周期素依赖性激酶、细胞周期调控与肝纤维化

作者:吴丹;谷秋红;李智伟 刊名:世界华人消化杂志 上传者:李莉

【摘要】肝纤维化是多种肝脏疾病的共同病理学结局.在肝纤维化过程中,肝星状细胞(hepatic stellate cells,HSCs)发生活化,表型发生改变,使其具有收缩性、再生性,并能生成胶原成分.肝纤维化的发生发展与活化的HSCs的增殖情况有关;而细胞增殖情况则与细胞周期素依赖性激酶、细胞周期调控密切相关.但是,目前对与此相关的分子机制尚未明确.此综述就近年来与肝纤维化过程中细胞周期素依赖性激酶及细胞周期调控方面的研究加以总结,以揭示可能存在的引起肝纤维化的部分机制.

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2013-08-08|Volume 21|Issue 22|WCJD|www.wjgnet.com wcjd@wjgnet.com 世界华人消化杂志 2013年8月8日; 21(22): 2158-2163 ISSN 1009-3079 (print) ISSN 2219-2859 (online) 文献综述 REVIEW 细胞周期素依赖性激酶、细胞周期调控与肝纤维化吴 丹, 谷秋红, 李智伟 ® 吴丹, 谷秋红, 李智伟, 中国医科大学附属盛京医院感染科 辽宁省沈阳市 110022 吴丹, 讲师, 主治医师, 主要从事肝炎、肝硬化及其他传染性疾病的临床、教学及科研工作. 作者贡献分布: 本文综述由吴丹与谷秋红完成; 吴丹贡献较多; 李智伟负责审校. 通讯作者: 李智伟, 教授, 主任医师, 博士生导师, 110022, 辽宁省沈阳市铁西区滑翔路39号, 中国医科大学附属盛京医院感染 科. lizw@sj-hospital.org 收稿日期: 2013-03-15 修回日期: 2013-06-03 接受日期: 2013-07-03 在线出版日期: 2013-08-08 Cyclin-dependent kinases, control of cell cycle and hepatic fi brosis Dan Wu, Qiu-Hong Gu, Zhi-Wei Li Dan Wu, Qiu-Hong Gu, Zhi-Wei Li, Department of Infec-tious Diseases, Shengjing Hospital of China Medical Uni-versity, Shenyang 110022, Liaoning Province, China Correspondence to: Zhi-Wei Li, Professor, Chief Physi-cian, Department of Infectious Diseases, Shengjing Hospi-tal of China Medical University, 39 Huaxiang Road, Tiexi District, Shenyang 110022, Liaoning Province, China. lizw@sj-hospital.org Received: 2013-03-15 Revised: 2013-06-03 Accepted: 2013-07-03 Published online: 2013-08-08 Abstract Multiple etiologies of liver disease lead to liver fi brosis by driving the activation of hepatic stel-late cells (HSCs) into a myofi broblast-like phe-notype that is contractile, proliferative and fi bro-genic. Liver fi brosis is associated with the pro-liferation of HSCs, and the cell cycle of activated HSCs is abnormal. Cyclin-dependent kinases (CDKs) play essential roles in cell proliferation. However,

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