Concurrent Chemoradiotherapy for Esophageal Cancer With Malignant Fistula

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【作者】 Ryuta Koike  Yasumasa Nishimura  Kiyoshi Nakamatsu  Shuichi Kanamori  Toru Shibata 

【关键词】Esophageal cancer  Chemoradiation  Esophageal fistulae 

【出版日期】2008-01-01

【摘要】The Pd-catalyzed hydroarylation of &#x3b2;-(2-aminoaryl)-<img src="http://www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">,&#x3b2;-ynones with organoboron derivatives, leading to 2,4-diarylquinolines in good to excellent yields through sequential cycloamination, has been investigated. The reaction is catalyzed by both Pd(II) and Pd(0) precatalysts, and can be carried out even under neutral conditions. The regiochemical outcome is inverted with respect to the Pd-catalyzed hydroarylation of &#x3b2;-(2-aminoaryl)-<img src="http://www.sciencedirect.com/scidirimg/entities/204e.gif" alt="greek small letter alpha" title="greek small letter alpha" border="0">,&#x3b2;-ynones with aryl iodides. This aspect has been rationalized using quantum-chemical calculations, which show significant differences between the energy barriers of the regioisomeric transition states for the migratory insertion (hydropalladation) step, and are consistent with the charge density of the &#x3c0; complex that undergoes such insertion.

【刊名】International Journal of Radiation Oncology*Biology*Physics

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