血清肿瘤标志物在上皮性卵巢癌早期诊断中研究进展

作者:辛亚兰;王卡娜;何荣霞 刊名:中国妇幼保健 上传者:何洪怀

【摘要】卵巢癌在妇科肿瘤中发病率仅次于宫颈癌和子宫体癌居第三位,而其致死率却占首位〔1〕。卵巢癌早期症状隐匿,鉴别其组织类型及良恶性相当困难,超过70%的患者就诊时已为晚期。资料显示,早期卵巢癌(Ⅰ期)5年存活率可达

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亚兰等 血清肿瘤标志物在上皮性 卵巢癌 期诊断 中研究进展 第 10期 没有任何一条途 径在 细胞 的某种 反应 中是 独立 存在 的,每 条 途径都可以和许多其他途径相整合,它们的强度、相互作用 、 整合结果决定 了细胞 的命运 。 5 参考文献 1 Ahnog T,Naor Z.Mitogen activated protein kinases(MAPKs)as regula— tors of spermatogenesis and spermatozoa functions[J].Molecular Cel lular Endocrinology,2008,282 (1—2):39 2 Perry AC, Verlhac MH.Second meiotic arrest and exit in frogs and mice [J].EMBO Rep,2008,9 (3):246 3 Lee SE, Kim JH, Kim NH, et a1.Inactivation of MAPK affects centro。 some assembly, but not actin filament assembly, in mouse oocytes ma- turing in vitro[J].Mol Reprod,2007,74 (7):904 4 Fan HY,Liu Z,Shinmda M,et a1.MAPK3/I (ERK1/2)in ovarian granulosa cells are essential for female fertility [J].Science,2009, 324:938 5 Motola S, Cao X , Popliker M , et a1.Involvement of mitogen~ activa ted protein kinase(MAPK)pathway in LH— and meiosis—activating sterol(MAS) 一induced maturation in rat and mouse oocytes(J].Mol Reprod Dev,2008,75 (10):I533 6 Shaul YD,Seger R.The MEK/ERK cascade:from signaling specificity to diverse functions[J].Biochim Biophys Acta,2007,1773(8):1213 7 GonzOlez R, Ruiz—Le6n Y, Gomendio M ,et a1.The effect of glu. coeorticoids on ERK ——1/2 phosphorylation during maturation of lamb o. ocytes and their subsequent fertilization and cleavage ability in vitro [J].Reprod Toxicol,2010,29 (2):198 8 Russo C,Beaujois R,Bodart JF,et a1.Kicked by MOS and tuned bv MPF—the initiation of the MAPK cascade in xenopus ooeytes[J].HF— SP J,2009,3 (6):428 9 Amid A, Lecl~re L, Robert L , eI aL

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