伊立替康联合氟尿嘧啶、砸叶酸钙二线治疗晚期结直肠癌的临床观察

作者:曾继泽;周航;刘霄 刊名:中国药房 上传者:王平

【摘要】目的:观察FOLFIRI方案二线治疗晚期结直肠癌的疗效及安全性。方法:28例FOLFOX4化疗失败的患者,改用FOLFIRI方案挽救化疗。结果:完全缓解为0例,部分缓解6例,稳定16例,进展6例,有效率21.4%。不良反应主要为恶心、呕吐、白细胞减少和延迟性腹泻。结论:FOLFIRI方案二线治疗晚期结直肠癌,疗效肯定,不良反应可控制。

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伊立替康联合氟尿嘧啶、 叶酸钙二线治疗晚期结直肠癌的临床观察 曾继泽 ,周 航,刘 霄(遵义医学院附属医院肿瘤医院二病区,遵义市 563003) 中图分类号 R979.1;R969.4 文献标识码 A 文章编号 1001 0408(2008)23—1812 02 摘 要 目的:观察 FOLF1RI方案二线治疗晚期结直肠癌的疗效及安全性=方法:28例 FOLFOX4化疗?v~e-j患者,改用 FOLF1RI方案挽救化疗。结果:完全缓解为0例,部分缓解6例,稳定16例,进展 6例,有效率21.4%。不良反应主要为恶心、呕吐、 白细胞减少和延迟性腹 泻。结论 :FOLFIRI方案二线治疗晚期结直肠癌 ,疗效肯 定,不 良反应可控 制。 关键词 伊立替康;氟尿嘧啶;亚叶酸钙;晚期结直肠癌;化学治疗 Clinical Observation of Irinotecan in Combination of Fluorouracil and Calcium Folinate as A Second Line Treatment for Advanced Colorectal Cancer ZENG J i-ze,ZHOU Hang.LIU Xiao(Second Endemic Area,The Affiliated Tumor Hospital Of Zunyi MedicaI College,Zunvj 563003,China) ABSI、RACT OBJE(7I’IVE: Fo observe the clinic efficacy and safety of FOLFIRI as a second Iine treatment for patients with advanced colorectal cancer.METHODS:Twenty—eight patients with advanced colorectal cancer whose disease progressed after first treatment with FOLFoX4 were included to receive the second Iine treatment with FOLFIRI regimen.RESULTS: Of the total 28 cases,0 had complete response,6 partial response,16 stable disease,6 progressive disease,and the responsive rate was 21.4% .The majority of adverse reaction was nausea,vomiting,leucopenia and tardive diarrhea.CoNCLUS10N:As a second line therapy,FOI FIRI has a confirmed therapeutic response and tolerable toxicity in patients with advanced colorectal can ce15 . KEY WORDS Irinotecan;FluorouraciI;Calcium folinate:Advanced colorectaI cancer;Chemotherapy 晚期结 卣肠癌患者的5 a生仔率不到 10% ,姑息化疗能 延长生存期,提高生

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