重症药疹85例临床分析

作者:申卉;Tomy Martin;李惠 刊名:中国皮肤性病学杂志 上传者:严秀将

【摘要】目的探讨重症药疹的临床特点及防治措施。方法对本科2002年8月-2013年11月诊治的重症药疹患者的临床资料进行回顾性分析。结果排名前三位的致敏药物分别为抗生素、抗癫痫药和解热镇痛药,最常见用药原因为感染。中成药引起的药疹内脏损害相对较轻。85例患者中,治愈61例,好转23例,1例死于肺部感染及呼吸衰竭。结论重症药疹是皮肤科危重病种,早期予以糖皮质激素联合免疫球蛋白效果较好,同时应加强对症及支持治疗。

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372 I呻f 连碱性病学余芯l嚣 姜 期 I OHm J ooRm VOflBRBOL l Apr 2015,Vol·29,No·4 重症药疹 85例临床分析 申卉 ,Tomy Martin,李惠 [摘 要] [关键词] 目的 探讨重症药疹的临床特点及防治措施。方法 对本科 2002年 8月 一2013年 11月诊治的重症 药疹患者的临床资料进行回顾性分析。结果 排名前三位的致敏药物分剐为抗生素、抗癫痫药和解热 镇痛药,最常见用药原因为感染。中成药引起的药疹 内脏损害相对较轻。85例患者中,治愈 61例 ,好 转 23例 ,1例死 于肺部 感染及 呼吸衰竭 。结论 重症药疹是皮肤 科危重病种 ,早期 予 以糖皮 质激素联 合免疫球蛋白效果较好,同时应加强对症及支持治疗。 重症 药疹 ;回顾 性分析 ;致敏 药物 [中图分类号] R 758.25 [文献标识码] B [文章编号] 1001—7089(2015)04—0372一o3 [DOI] 10.13735/j.cjdv.1001-7089.201409060 A Retrospective Clinical Analysis in 85 Cases of Severe Drug Eruptions SHEN Hui,Tomy Martin,LI Hui (The First Affiliated Hospital ofChongqing Medical University,Chongqing 400016,China) [Corresponding author] LI Hui,E—mail:1ihui5807 1 1@163.com [Abstract] Objective To investigate the clinical features and prevention measures of severe drug eruptions.Methods Clinical data of patients suffered from severe drug eruptions from August 2002 to November 2013 in our de- partment were analyzed retrospectively.Results The top three sensitization drugs were antibiotics,antiepi— leptic drugs and non—steroidal anti-inflammatory drugs.Infection was the most common reason for drug in- take.Allergy—induced by traditiOnal Chinese patent drug had less damage to internal organs.Sixty—one of 85 cases were cured,23 cases improved,only 1 case died of pulmonary infection and respiratory failure.Conclu- sion Severe drug eruptions are life—threatening cutaneous reactions.Combined usage of hormone and immu— noglobulin in early stage could achieve

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