High enhancer-loading polyacrylate formulation for transdermal applications

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【作者】 Jay  Jianye  Eli J.  Robert M.  Allison  Paul B.  Eric N. Audett  Wen  Goldman  Gale  Luciano  Foreman  Silverberg 

【摘要】A polyacrylate formulation suitable for delivery of drug through a body surface of an individual. By loading the drug and permeation enhancers at a high concentration into a polyacrylate proadhesive that has inadequate adhesive properties for typical adhesive application on the skin, a formulation with desirable adhesive characteristics and effective therapeutic properties can be made. The proadhesive has higher glass transition temperature than typical pressure sensitive adhesives.

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