寻常性银屑病患者外周血Th17/Treg平衡偏移的研究

作者:陈晋广;赖维;姜昱 刊名:中国中西医结合皮肤性病学杂志 上传者:杨向辉

【摘要】目的通过检测寻常性银屑病患者血清中Th17、Treg细胞的水平,探讨其在银屑病发病机制中的作用。方法选择46例寻常性银屑病患者和20例健康人为研究对象,采用流式细胞技术检测外周血Th17细胞和CD4+CD25+Treg细胞亚群。结果银屑病患者Th17表达水平明显高于正常对照组,而Treg与正常对照组比较差异无统计学意义;患者Th17/Treg表达水平与患者PASI评分呈正相关。结论银屑病患者外周血中Th17/Treg细胞表达失衡可能参与了其发病的过程。

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中国中西医结合皮肤性病学杂志 2013 年第 12 卷第 6 期 · · ·论著· 寻常性银屑病患者外周血 Th17/Treg 平衡偏移的 研究 陈晋广 1,2,赖维 3,姜昱 1 (1. 广东省中山市人民医院,中山 528403;2.浙江省台州市立医院,台州 318000;3. 中山大学附属第三医院,广州 510630) 摘要:目的 通过检测寻常性银屑病患者血清中 Th17、Treg 细胞的水平, 探讨其在银屑病发病机制中的作用。方法 选择 46 例寻常性银屑病患者和 20 例健康人为研究对象,采用流式细胞技术检测外周血 Th17 细胞和 CD4+ CD25+Treg 细胞亚群。结果 银屑病患者 Th17 表达水平明显高于正常对照组,而 Treg 与正常对照组比较差异无统计学意义;患者 Th17/Treg 表达水平与患者 PASI 评分呈正相关。结论 银屑病患者外周血中 Th17/Treg 细胞表达失衡可能参与了其发病的过程。 关键词:银屑病;辅助性 T 细胞 17;调节性 T 细胞 中图分类号:R758.63 文献标识码:A 文章编号:1672-0709(2013)06-0353-03 Study on the Shift of Th17/Treg in Patients with Psoriasis Vulgaris CHEN Jinguang1,2, LAI Wei3, JIANG Yu1 1. People's Hospital of Zhongshan City, Zhongshan 528403, China; 2. Taizhou Municipal Hospital, Taizhou 318000, China; 3. The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China Abstract:Objective To investigate the alteration and significance of Th17/Treg cell in patients with psoriasis vulgaris. Methods 46 patients were observed and 20 healthy people were enrolled as controls. The frequencies of Treg, Th17 in peripheralbloodweredetectedbyflowcytometricanalysis. Results The frequencies of Th17 in peripheral blood were significantlyincreasedinpsoriasis,comparedwithcontrols;andTh17/TregwerepositivecorrelatedwithPASI.Therewasno statisticaldifferencebetweenthetwogroupsinTreg. Conclusion Th17/Treg responsive model of psoriasis is different from that of controls, the alteration of Th17/Treg might play a roles in the pathogenesis of psoriasis. Key words: Psori

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