血清或血浆中的miR-375在肿瘤诊治和预后中的研究进展  

作者:王涛;吴敬波 刊名:《西南军医》 上传者:魏丽惠

【摘要】microRNAs(miRNAs)是一类在转录后水平调控基因表达的内源性非编码小RNA分子,通过与下游靶基因3’-非编码区(3’-untranslated regions 3’-UTRs)结合,抑制mRNA的翻译或使其降解,进而发挥原癌基因或抑癌基因的作用。近年来研究表明,血清或血浆中的miR.375是肿瘤早期诊断、治疗、预后等密切相关的生物标志。

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