纳米HAP/CPP/PLLA骨组织工程支架复合材料降解特性

作者:朱凌云;王彦平;石宗利;张红梅 刊名:兰州理工大学学报 上传者:蓝岚

【摘要】现有支架材料的降解速率与骨细胞生长、繁殖速率不匹配,在降解过程中支架材料的强度、刚度衰减速率与成骨速率不匹配,支架材料在体内降解的酸性副产物会引起炎症反应.为克服以上困难,采用溶媒浇铸、颗粒滤取与气体发泡相结合的方法制备出纳米HAP/CPP/PLLA骨组织工程支架复合材料;选用生理盐水作为模拟体液进行降解实验,测试该支架复合材料的降解性能,用扫描电子显微镜对其在不同降解时期的微观结构进行观察.结果表明:纳米HAP/CPP/PLLA支架复合材料在降解过程中具有三维、连通、微孔网状结构,并具有良好的降解性能和生物相容性,是比较理想的骨组织工程支架材料.

全文阅读

  文章编号:1673-5196(2012)02-0010-05 纳米 HAP/CPP/PLLA骨组织工程支架复合材料降解特性 朱凌云,王彦平,石宗利,张红梅 (兰州交通大学 机电工程学院,甘肃 兰州 730070) 摘要:现有支架材料的降解速率与骨细胞生长、繁殖速率不匹配,在降解过程中支架材料的强度、刚度衰减速率与成骨速率不匹配,支架材料在体内降解的酸性副产物会引起炎症反应.为克服以上困难,采用溶媒浇铸、颗粒滤取与气体发泡相结合的方法制备出纳米 HAP/CPP/PLLA骨组织工程支架复合材料;选用生理盐水作为模拟体液进行降解实验,测试该支架复合材料的降解性能,用扫描电子显微镜对其在不同降解时期的微观结构进行观察.结果表明:纳米 HAP/CPP/PLLA支架复合材料在降解过程中具有三维、连通、微孔网状结构,并具有良好的降解性能和生物相容性,是比较理想的骨组织工程支架材料.关键词:组织工程;支架;骨;复合材料;降解中图分类号:TB18  文献标识码:A Degradation characteristics of HAP/CPP/PLLA nanometercomposite for scaffold of osteo-tissue engineering ZHU Ling-yun,WANG Yan-ping,SHI Zong-li,ZHANG Hong-mei ( School of Mechatronics Engineering,Lanzhou Jiaotong University,Lanzhou 730070,China) Abstract:The degradation rate of scaffold material available does not match the growth and reproductionrate of osteo-cell,the attenuation rate of strength and stiffness of scaffold material does not match thebone generation rate in its degradation process,and the acidic by-product of degradation of the scaffold ma- terial in human body may cause inflammation reaction.In order to overcome above-mentioned difficulties,a HAP/CPP/PLLA manometer composite for scaffold of osteo-tissue engineering was fabricated with the technique of solvent-casting and particle-leaching combined with the method of gaseous foaming.Degrada-tion experiment was carried out with the physiological saline as simulative body fluids to test the degrada-tion performance of this scaffold composite.Its microscopic structure in different degradati

参考文献

引证文献

问答

我要提问