Synthesis, DNA-binding, and Photocleavage of 2,3-Di-2-pyridylquinoxaline-silver(I) Complex

作者:WANG Xiu-li FANG;Jia-ni BI;Yan-feng LIN;Hong-yan LIU;Guo-cheng 刊名:高等学校化学研究:英文版 上传者:韩子榕

【摘要】A new dinuclear complex, [Ag(L)(CH3CN)]2(ClO4)2·2H2O(L=2,3-di-2-pyridylquinoxaline), was prepared and characterized by elemental analyses, IR spectroscopy, and single-crystal X-ray diffraction analyses. The interaction of the complex with calf thymus DNA(CT-DNA) was investigated by absorption, fluorescence spectroscopies, and viscosity measurement. The results suggested that the complex was bound to DNA via an intercalative mode. The intrinsic binding constant value Kb was found to be approximately 1.48×10^3 L·mol^-1. Moreover, the Ag(I) complex could cleave the plasmid pUC19 DNA from the supercoiled Form Ⅰto the nicked FormⅡ under irradiation at 365 nm.

参考文献

引证文献

问答

我要提问