Synthesis and Crystal Structure of a 3-Arylamino-3-Deoxy Sugar Derivative

作者:JI Xiao-Ming SUN;He-Ping MO;Juan LIU;Hong-Min 刊名:结构化学 上传者:李二玲

【摘要】3-Deoxy-3-(p-fluorine-phenylamino)-1,2-O-isopropylidene-α-D-ribofuranose 3 was synthesized and characterized by IR, NMR and H R M S, and its crystal structure was detertnined by X-ray diffraction analysis. Crystal data for 3: monoclinic, space group P21, a=7.0403(14), b = 6.7780(4), c = 14.932(3) A, β= 94.74(3)°, C14H18FNO4, Mr = 283.29, V= 710.1(2) A^3, Z = 2, Dc = 1.325 g/cm^3, μ = 0.105 mm^-1, F(000) = 300, the final R = 0.0468 and wR = 0.0926 for 1969 observed reflections (I 〉 2σ(I)). Two intermolecular hydrogen bonds are observed. The absolute configuration of this molecule was confirmed by comparison with that of the original material.

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