Urinary follicle stimulating hormone can be used as a biomarker to assess male reproductive function

作者:Xin-RuWANG JamesWOverstreet;HeatherTodd QingQIU;Jiang-HuaYANG Shu-YiWANG Xi-PingXU BillLLasley 刊名:亚洲男性学杂志:英文版 上传者:王文星

【摘要】Aim: To develop an algorithm for use in population-based studies to assess testicniar function by measurements of total urinary follicle stimulating hormone (FSH). Methods: Total concentrations of unnary FSH were measured in a group of 44 men at the University of Califomia, Davis (UCD) and were compared to FSH measurements in serum. On the basis of these and other published data, a urinary FSH value of>2 ng/mg creatinine (Cr) was selected as the cutoffpoint to identify men with elevated serum FSH ( > 12 IU/L) or low sperm counts ( < 20 million/mL). Results: Thesensitivity and specificity of this algorithm for detecting elevated serum FSH in a group of 58 agricultural workers in thePeople' s Republic of China were 100 % and 50 %, respectively. The sensitivity and specificity of this algorithm fordetecting low sperm counts in a population of 105 infertility patients at UCD were 58 % and 76 %, respectavely.Conclusion: This test may have particular value in identifying populations with no evidence of testicular toxicity, andin which labor-intensive semen studies may not be feasible. (As/an JAndrol 1999; 1 : 67 - 72)

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