Inflammatory biomarkers: impact for diabetes and diabetic vascular disease

作者:Marijan Bosevski[1];Lily Stojanovska[2];Vasso Apostolopoulos[2] 刊名:生物化学与生物物理学报:英文版 上传者:邱瑜

【摘要】Physical inactivity and sedentary lifestyles are believed to be independ- ent risk factors for the occurrence of obesity, type-2 diabetes, and metabolic syndrome [1-3]. The incidence of type-2 diabetes character- ized by chronic hyperglycemia and glucose intolerance, has increased in parallel with obesity, and as of 2010, 285 million people were diag- nosed with type-2 diabetes compared with 30 million 25 years ago [4]. Even with statin therapy, type-2 diabetes has been shown to lead to accelerated atherosclerosis and excessive risk of vascular disease [5]. Risk factors such as hyperglycemia and glucose intolerance, hyperlip- idemia, obesity, and hypertension lead to diabetic vascular disease [6]. It is not well understood why some patients with the same duration of diabetes and metabolic control have different extents of atheroscler- osis spread through multiple vascular regions or limited to only one vascular territory. Use of statins and fibrates in people with type-2 dia- betes are favorable, despite the progression of diabetic vascular disease [7]. However, co-administration of pioglitazone and statins provides regression in intima-media thickness and endothelial function im- provement [8]. In addition, a decrease of inflammatory markers (C-reactive protein; CRP, P-selectin, adiponectin, and high density lipoprotein cholesterol) and triglyceride levels were noted in patients with increased cardiovascular risk factors [8]. There is limited infor- mation on the potentially unique features of this inflammatory process in diabetic vascular disease.

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