,β-ynones with organoboron derivatives, leading to 2,4-diarylquinolines in good to excellent yields through sequential cycloamination, has been investigated. The reaction is catalyzed by both Pd(II) and Pd(0) precatalysts, and can be carried out even under neutral conditions. The regiochemical outcome is inverted with respect to the Pd-catalyzed hydroarylation of β-(2-aminoaryl)-greek small letter alpha,β-ynones with aryl iodides. This aspect has been rationalized using quantum-chemical calculations, which show significant differences between the energy barriers of the regioisomeric transition states for the migratory insertion (hydropalladation) step, and are consistent with the charge density of the π complex that undergoes such insertion." />
/0

Concurrent Chemoradiotherapy for Esophageal Cancer With Malignant Fistula

资源类型:pdf 资源大小:100.00KB 文档分类: 刊名: International Journal of Radiation Oncology*Biology*Physics 
作者: Ryuta Koike  Yasumasa Nishimura  Kiyoshi Nakamatsu  Shuichi Kanamori  Toru Shibata 

相关文档

批量下载下列文档
众筹精品平台