The impact of indirect (herd) protection on the cost-effectiveness of pneumococcal conjugate vaccine

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【作者】 Daniel J. Isaacman  David R. Strutton  Edward A. Kalpas  Nathalie Horowicz-Mehler  Lee S. Stern  Roman Casciano  Vincent Ciuryla 

【关键词】Prevnar  PCV7  indirect effects  cost-effectiveness  herd effects  sensitivity analysis 


【摘要】Background: The heptavalent pneumococcal polysaccharide-protein conjugate vaccine (PCV7) confers protection against invasive pneumococcal disease (IPD) caused by serotypes that are responsible for substantial morbidity and mortality throughout the world. In 2000, the 7 serotypes covered by PCV7 accounted for 80%to 90%of serotypes isolated from the blood or cerebrospinal fluid of children aged <6 years in the United States. A previous review of the literature spanning the years 1998 to 2005 pertaining to the incidence of IPD among nonimmunized individuals in countries with universal PCV7 immunization suggested an indirect protective effect (herd protection, or community immunity) after widespread vaccination. Consideration of indirect protection against IPD may enhance cost-benefit evaluations of vaccination programs.

【刊名】Clinical Therapeutics